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Effect of imidazolium room-temperature ionic liquids on aggregation of amphotericin B: A circular dichroism study

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The Royal Society of Chemistry
Date
2015-09-17
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Abstract
The nature of the anion of imidazolium-based ionic liquids was found to control the aggregate-monomer equilibrium of amphotericin B. This is in contrast to aqueous solutions of inorganic salts and imidazolium-based ionic liquids, which were previously found to favor the disaggregation of amphotericin B. The results further establish the designer solvent ability of ionic liquids, specifically as it relates to their ability to influence intermolecular interactions.
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Self-association
 electronic absorption
 polyene antibiotics
 solvation
 polarity
 drugs
 salts
 ergosterol
 dynamics
 behavior
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Chemistry and Biochemistry
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URI
https://repository.tcu.edu/handle/116099117/11217
 https://pubs.rsc.org/en/Content/ArticleLanding/2015/RA/C5RA17077J
DOI
https://doi.org/10.1039/C5RA17077J