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Chronic Sleep Restriction Exacerbates Alzheimer's Disease-Like Pathology And Alters Peripheral Il-1beta Expression In C57BL/6 Mice
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2020
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Alzheimer’s Disease, a devastating neurodegenerative disease characterized by amyloid-beta plaques and neurofibrillary tangles, is the 6th leading cause of death in the U.S., and its prevalence is increasing. A common feature of Alzheimer’s is a disrupted sleep/wake cycle. 35.3% of adults in the U.S. get less than the minimum 7 hours of sleep per night recommended by the National Sleep Foundation. Interestingly, evidence suggests a bidirectional relationship between sleep loss and Alzheimer’s. We hypothesized that six weeks of sleep restriction would lead to increased amyloid-beta in the hippocampus and cognitive deficits in C57BL/6 mice. Further, we hypothesized that these effects would be exacerbated by intraperitoneal LPS administration. Chronic sleep restriction itself was associated with cognitive deficits in contextual fear conditioning, increased hippocampal amyloid-beta, and alteration in the circadian fluctuation in serum IL-1ß. Furthermore, LPS administration coupled with chronic sleep restriction led to exacerbated cognitive dysfunction.
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27667701.pdf
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1 online resource (v, 52 pages) :
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Psychology