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Sexual maturity status as a confounding variable in fish-based screening assays for the detection of anti-estrogens and non-aromatizable androgens
Roush, Kyle Stephan,author.
Roush, Kyle Stephan,author.
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2018
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Reproductive endocrine disrupting compounds (REDCs) in the environment pose a potential threat to fish, as exposures are capable of altering reproduction. Fish-based screening assays are utilized to screen for the presence of REDCs in surface waters and to assess single chemicals for potential endocrine activity. To improve such assays, the goal of this project was to determine whether less and more sexually mature females differed in their responses to the model anti-estrogen fadrozole (FZ) and the model androgen 17ß-trenbolone (TB). Less mature females were more sensitive to FZ and a high concentration of TB, while the more mature females were more sensitive to a low concentration of TB. The differential responses of these females indicate that maturity status influences REDC exposure outcome and should subsequently be taken into consideration in the implementation of screening assays.
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1 online resource (v, 37 pages) :
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Biology