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The reproductive effects of thyroid disruption in the fathead minnow (Pimephales promelas)
Bruns, Peter Charles,author.
Bruns, Peter Charles,author.
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2017
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Research on the effects of exposure to thyroid disrupting compounds has typically focused on endpoints involved in thyroid hormone signaling (e.g., thyroid hormone concentration) and development of juveniles. However, it has been shown that thyroid disruption can impact reproductive function. Developmental exposure effects may be permanent even after depuration. The goal of this study was to identify the effects of adult and early-life-stage exposure to model thyroid disruptors on reproductive function in fathead minnows (Pimephales promelas). This species is commonly used as a model organism in toxicity testing, but the reproductive outcomes of thyroid disruption are not well understood in this species. The results showed that there were few alterations in exposed adults. However, developmental thyroid inhibition led to a significant decrease in reproductive output. While the mechanism behind this change is not known, the results show the potential risk of developmental thyroid disruption on reproductive endpoints.
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1 online resource (vi, 83 pages) :
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Biology