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Determining mechanism of action of antivirals for respiratory infections
Rodriguez Garcia, Irma Thalia
Rodriguez Garcia, Irma Thalia
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[Fort Worth, Tex.] : Texas Christian University,
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2016
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Viral infections in the respiratory tract are common in humans and can cause serious illness and death. Drug treatment is the principal line of protection against many of these illnesses and many compounds are tested as antivirals. Often the efficacy of these antivirals are determined before a mechanism of action is understood. We use mathematical models to represent the evolution of influenza and establish which experiments can help determine the mechanism of action of antivirals. We find that curves describing the effect of a drug are dependent on the quantity being measured and that the predicted shape of the curves is dependent on model parameters.--Abstract.
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Physics and Astronomy