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dc.contributor.authorCanipe, Matthew
dc.date.accessioned2016-09-14T15:32:01Z
dc.date.available2016-09-14T15:32:01Z
dc.date.issued2016-05-19
dc.identifier.urihttps://repository.tcu.edu/handle/116099117/11327
dc.description.abstractThe Green Research Group has previously synthesized molecules that are capable of combating the hallmarks of Alzheimer?s disease and preventing and reversing amyloid beta aggregate formation. While preliminary studies show that these ligands are able to cross the blood brain barrier to an extent, it is important to enhance this property of the ligands. In this study, we apply a common technique to increase blood brain barrier permeability, glycosylation, to the L2 and L3 ligands. New synthetic pathways and reactions were created to achieve glycosylation, and the newly synthesized molecules were characterized using 1H NMR, 13C NMR, and mass spectrometry.
dc.subjectAlzheimer's Disease
dc.subjectGlycosylation
dc.titleENHANCING BLOOD BRAIN BARRIER PERMEABILITY OF THERAPUETIC AGENTS FOR ALZHEIMER?S DISEASE BY ADDING GLUCOSE.en_US
etd.degree.departmentChemistry


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