SYNTHESIS OF 2,4,6-TRISUBSTITUTED-1,3,5-TRIAZINE USING SERTRALINE AS ONE OF THE SUBSTITUENTSShow full item record
SYNTHESIS OF 2,4,6-TRISUBSTITUTED-1,3,5-TRIAZINE USING SERTRALINE AS ONE OF THE SUBSTITUENTS
Besides its commercial use as an anti-depressant, sertraline is also known to behave as an efflux pump inhibitor which impedes bacteria?s ability to extrude antibiotic. This property explains why sertraline can potentiate clinically relevant antibiotics and make them effective against some resistant strains of bacteria. Exploiting this characteristic, a library of 2,4,6-trisubstituted-1,3,5-triazines were synthesized, using sertraline as one of the substituents while the other substituent groups were varied. The synthesized compounds were screened for antibacterial activities using Kirby-Bauer disk diffusion method. Of the seven new compounds prepared, three showed noteworthy activity against both Gram negative and Gram positive bateria, Staphylococcus aureus and Escherichia coli, respectively.