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dc.creatorCampbell, Elizabeth
dc.creatorHasan, Md. Tanvir
dc.creatorPho, Christine
dc.creatorCallaghan, K.
dc.creatorAkkaraju, Giridhar R.
dc.creatorNaumov, Anton V.
dc.date.accessioned2019-07-11T15:17:09Z
dc.date.available2019-07-11T15:17:09Z
dc.date.issued2019-01-23
dc.identifier.urihttps://doi.org/10.1038/s41598-018-36617-4
dc.identifier.urihttps://repository.tcu.edu/handle/116099117/26378
dc.identifier.urihttps://www.nature.com/articles/s41598-018-36617-4
dc.description.abstractGraphene oxide (GO), the most common derivative of graphene, is an exceptional nanomaterial that possesses multiple physical properties critical for biomedical applications. GO exhibits pH-dependent fluorescence emission in the visible/near-infrared, providing a possibility of molecular imaging and pH-sensing. It is also water soluble and has a substantial platform for functionalization, allowing for the delivery of multiple therapeutics. GO physical properties are modified to enhance cellular internalization, producing fluorescent nanoflakes with low (<15%) cytotoxicity at the imaging concentrations of 15 µg/mL. As a result, at lower flake sizes GO rapidly internalizes into HeLa cells with the following 70% fluorescence based clearance at 24 h, assessed by its characteristic emission in red/near-IR. pH-dependence of GO emission is utilized to provide the sensing of acidic extracellular environments of cancer cells. The results demonstrate diminishing green/red (550/630 nm) fluorescence intensity ratios for HeLa and MCF-7 cancer cells in comparison to HEK-293 healthy cells suggesting a potential use of GO as a non-invasive optical sensor for cancer microenvironments. The results of this work demonstrate the potential of GO as a novel multifunctional platform for therapeutic delivery, biological imaging and cancer sensing.en_US
dc.language.isoenen_US
dc.publisherNature Publishing Group
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/
dc.sourceScientific Reports
dc.subjectDrug deliveryen_US
dc.subjectImaging techniques and agentsen_US
dc.subjectNanotechnology in canceren_US
dc.titleGraphene Oxide as a Multifunctional Platform for Intracellular Delivery, Imaging, and Cancer Sensing
dc.typeArticleen_US
dc.rights.holderCampbell et al.
dc.rights.licenseCC BY 4.0
local.collegeCollege of Science and Engineering
local.departmentPhysics and Astronomy
local.departmentBiology
local.personsCampbell, Hasan, Pho, Naumov (PHYS); Callaghan, Akkaraju (BIOL)


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