dc.creator | Campbell, Elizabeth | |
dc.creator | Hasan, Md. Tanvir | |
dc.creator | Pho, Christine | |
dc.creator | Callaghan, K. | |
dc.creator | Akkaraju, Giridhar R. | |
dc.creator | Naumov, Anton V. | |
dc.date.accessioned | 2019-07-11T15:17:09Z | |
dc.date.available | 2019-07-11T15:17:09Z | |
dc.date.issued | 2019-01-23 | |
dc.identifier.uri | https://doi.org/10.1038/s41598-018-36617-4 | |
dc.identifier.uri | https://repository.tcu.edu/handle/116099117/26378 | |
dc.identifier.uri | https://www.nature.com/articles/s41598-018-36617-4 | |
dc.description.abstract | Graphene oxide (GO), the most common derivative of graphene, is an exceptional nanomaterial that possesses multiple physical properties critical for biomedical applications. GO exhibits pH-dependent fluorescence emission in the visible/near-infrared, providing a possibility of molecular imaging and pH-sensing. It is also water soluble and has a substantial platform for functionalization, allowing for the delivery of multiple therapeutics. GO physical properties are modified to enhance cellular internalization, producing fluorescent nanoflakes with low (<15%) cytotoxicity at the imaging concentrations of 15 µg/mL. As a result, at lower flake sizes GO rapidly internalizes into HeLa cells with the following 70% fluorescence based clearance at 24 h, assessed by its characteristic emission in red/near-IR. pH-dependence of GO emission is utilized to provide the sensing of acidic extracellular environments of cancer cells. The results demonstrate diminishing green/red (550/630 nm) fluorescence intensity ratios for HeLa and MCF-7 cancer cells in comparison to HEK-293 healthy cells suggesting a potential use of GO as a non-invasive optical sensor for cancer microenvironments. The results of this work demonstrate the potential of GO as a novel multifunctional platform for therapeutic delivery, biological imaging and cancer sensing. | |
dc.language.iso | en | en_US |
dc.publisher | Nature Publishing Group | |
dc.rights.uri | https://creativecommons.org/licenses/by/4.0/ | |
dc.source | Scientific Reports | |
dc.subject | Drug delivery | |
dc.subject | Imaging techniques and agents | |
dc.subject | Nanotechnology in cancer | |
dc.title | Graphene Oxide as a Multifunctional Platform for Intracellular Delivery, Imaging, and Cancer Sensing | |
dc.type | Article | |
dc.rights.holder | Campbell et al. | |
dc.rights.license | CC BY 4.0 | |
local.college | College of Science and Engineering | |
local.department | Physics and Astronomy | |
local.department | Biology | |
local.persons | Campbell, Hasan, Pho, Naumov (PHYS); Callaghan, Akkaraju (BIOL) | |