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dc.contributor.advisorMinter, David E.
dc.contributor.authorWinslow, Christopher Daviden_US
dc.date.accessioned2019-10-11T15:10:03Z
dc.date.available2019-10-11T15:10:03Z
dc.date.created2000en_US
dc.date.issued2000en_US
dc.identifieraleph-892203en_US
dc.identifierMicrofilm Diss. 773.en_US
dc.identifier.urihttps://repository.tcu.edu/handle/116099117/31834
dc.description.abstractThe preparation of the galanthan skeleton was achieved in 7 steps with a 35% overall yield from isocarbostyril. The crucial step in this process involved the first reported intramolecular de Mayo reaction of an isocarbostyril substrate. The first intermolecular de Mayo reaction of an isocarbostyril is also depicted. A simple and inexpensive method for the preparation of isocarbostyril from isoquinoline was developed. This method utilized the straightforward and efficient cleavage of the N-vinyl amide group with a relatively mild acidic solution at ambient temperature. A brief examination of the reactivity of isocarbostyril substrates in the intramolecular Diels-Alder reaction is also reported. Work utilizing this method as the key step in producing the galanthan skeleton proved unsuccessful but inspired a number of intriguing questions and established the basis for a number of interesting research projects.en_US
dc.format.extentvii, 112 leaves : illustrationsen_US
dc.format.mediumFormat: Printen_US
dc.language.isoengen_US
dc.relation.ispartofTexas Christian University dissertationen_US
dc.relation.ispartofAS38.W5686en_US
dc.subject.lcshIsoquinolineen_US
dc.subject.lcshAlkaloidsen_US
dc.titleA methods development approach towards the Galanthan skeleton starting with isoquinolineen_US
dc.typeTexten_US
etd.degree.departmentDepartment of Chemistry
etd.degree.levelDoctoral
local.collegeCollege of Science and Engineering
local.departmentChemistry and Biochemistry
local.academicunitDepartment of Chemistry
dc.type.genreDissertation
local.subjectareaChemistry and Biochemistry
dc.identifier.callnumberSpecial Collections: AS38 .W5686 (Non-Circulating)
etd.degree.nameDoctor of Philosophy
etd.degree.grantorTexas Christian University


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