Show simple item record

dc.contributor.advisorBarth, Timothy M.
dc.contributor.authorBarbay, Scotten_US
dc.identifierMicrofilm Diss. 629en_US
dc.description.abstractBehavioral recovery was assessed following two different size lesions. In experiment 1 large unilateral electrolytic lesions including both the caudal and rostral forelimb representations of the rat's somatosensory cortex were used. In experiments 2 and 3 small unilateral electrolytic lesions were restricted to the caudal forelimb representation. The effects of MK-801, a neuroprotective agent known for its effectiveness in attenuating excitotoxic cell death, was assessed following both of these lesions. The large lesion produced chronic placing deficits with the contralateral forelimb, and chronic ipsilateral asymmetries measured over six months. MK-801 (1mg/kg; i.p.) given after the large lesion was not effective in attenuating the placing deficits, but was effective in promoting recovery from ipsilateral asymmetries. The small lesion produced transient contralateral placing deficits and ipsilateral asymmetries. MK-801 (1mg/kg; i.p.) given after the small lesion enhanced recovery from all deficits. The beneficial effects of MK-801 upon recovery were associated with its neuroprotective effects observed in the ipsilateral striatum.
dc.format.extentxiii, 180 leaves : illustrationsen_US
dc.format.mediumFormat: Printen_US
dc.relation.ispartofTexas Christian University dissertationen_US
dc.subject.lcshBrain damage--Treatment--Laboratory animalsen_US
dc.subject.lcshCerebral ischemia--Treatment--Laboratory animalsen_US
dc.titleThe effects of MK-801, a neuroprotective agent, upon recovery of function from cortical damageen_US
dc.typeTexten_US of Psychology
local.collegeCollege of Science and Engineering
local.academicunitDepartment of Psychology
dc.identifier.callnumberMain Stacks: AS38 .B363 (Regular Loan)
dc.identifier.callnumberSpecial Collections: AS38 .B363 (Non-Circulating) of Philosophy Christian University

Files in this item


There are no files associated with this item.

This item appears in the following Collection(s)

Show simple item record