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dc.contributor.advisorBobich, Joseph A.
dc.contributor.authorYang, Ming-Huien_US
dc.date.accessioned2014-07-22T18:47:14Z
dc.date.available2014-07-22T18:47:14Z
dc.date.created2007en_US
dc.date.issued2007en_US
dc.identifieretd-04202007-153701en_US
dc.identifiercat-001315423en_US
dc.identifier.urihttps://repository.tcu.edu:443/handle/116099117/4034
dc.description.abstractAquaporin-9 (AQP9) is a neutral channel, permeable to water, glycerol, and a number of solutes. The presence of AQP9 in retinal ganglion cells (RGCs) was confirmed. AQP9 and a number of proteins responded differently to two animal models of glaucoma. Inhibition of AQP9 may protect RGCs under hypoxia conditions. The expression of AQP9 responded to hypotonic shock in a time-dependent matter. Aquaporin in the RGCs and astrocytes may play a role in cell survival or death, depending on the stimulus. Under some conditions, increasing AQP4 may also be protective, such as in vasogenic edema, whereas under cytotoxic edema it becomes detrimental. This work describes possible physiological and pathophysiological roles of AQP9. Aquaporin-4 is expressed in astrocytes, which are considered RGCs supportive cells. AQP4 may be targeted by the proteasome system, so inhibition of this pathway may be protective in vasogenic brain edema.
dc.format.mediumFormat: Onlineen_US
dc.language.isoengen_US
dc.publisherFort Worth, Tex. : Texas Christian University,en_US
dc.relation.ispartofTexas Christian University dissertationen_US
dc.relation.ispartofUMI thesis.en_US
dc.relation.requiresMode of access: World Wide Web.en_US
dc.relation.requiresSystem requirements: Adobe Acrobat reader.en_US
dc.subject.lcshAquaporins.en_US
dc.subject.lcshRetinal ganglion cells.en_US
dc.subject.lcshGlaucoma.en_US
dc.titleA water channel (AQP9) in retinal ganglion cell apoptosis and glaucomaen_US
dc.typeTexten_US
etd.degree.departmentDepartment of Chemistry
etd.degree.levelDoctoral
local.collegeCollege of Science and Engineering
local.departmentChemistry and Biochemistry
local.academicunitDepartment of Chemistry and Biochemistry
dc.type.genreDissertation
local.subjectareaChemistry and Biochemistry
etd.degree.nameDoctor of Philosophy
etd.degree.grantorTexas Christian University


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