Show simple item record

dc.contributor.authorNorris, Jacob Nen_US
dc.date.accessioned2014-07-22T18:47:45Z
dc.date.available2014-07-22T18:47:45Z
dc.date.created2009en_US
dc.date.issued2009en_US
dc.identifieretd-10152009-100239en_US
dc.identifierumi-10067en_US
dc.identifiercat-001495625en_US
dc.identifier.urihttps://repository.tcu.edu:443/handle/116099117/4175
dc.descriptionTitle from dissertation title page (viewed Oct. 30, 2009).en_US
dc.descriptionIncludes abstract.en_US
dc.descriptionThesis (Ph.D.)--Texas Christian University, 2009.en_US
dc.descriptionDepartment of Psychology; advisor, Mauricio R. Papini.en_US
dc.descriptionIncludes bibliographical references.en_US
dc.descriptionText (electronic thesis) in PDF.en_US
dc.descriptionFour experiments using the partial agonist D-cycloserine (DCS) were conducted to investigate the role of the N-methyl D-aspartate (NMDA) receptor in consummatory successive negative contrast (cSNC), an animal model of loss-induced anxiety. . In Experiment 1, pretrial 11 and 12 administration of DCS (30 mg/kg) enhanced cSNC following the reward downshift from 32%-to-4% sucrose solution. In Experiment 2, posttrial 11 administration of DCS enhanced cSNC greatest at 30 mg/kg, following 32%-to-4%, and mildly following 32%-to-6%. In Experiment 3, DCS at 15 mg/kg and 60 mg/kg prolonged cSNC mildly (32%-to-4%). Experiment 4 suggested enhancement was not the result of conditioned taste aversion (CTA) to DCS (30 mg/kg); CTA to novel 4% solution failed to develop, compared to unpaired and saline controls. Results were interpreted to mean that activation of NMDA receptors via the glycine-modulatory site enhances the aversive memory associated with unexpected reward loss. Possible applications for therapeutic settings are discussed.en_US
dc.format.mediumFormat: Onlineen_US
dc.language.isoengen_US
dc.publisher[Fort Worth, Tex.] : Texas Christian University,en_US
dc.relation.ispartofTexas Christian University dissertationen_US
dc.relation.ispartofUMI thesis.en_US
dc.relation.ispartofTexas Christian University dissertation.en_US
dc.relation.requiresMode of access: World Wide Web.en_US
dc.relation.requiresSystem requirements: Adobe Acrobat reader.en_US
dc.subject.lcshMethyl aspartate Receptors.en_US
dc.subject.lcshAnxiety.en_US
dc.subject.lcshMemory.en_US
dc.subject.lcshFear Physiological aspects.en_US
dc.titleRole of the NMDA receptor in consummatory successive negative contrast [electronic resource] /en_US
dc.typeTexten_US
etd.degree.departmentDepartment of Psychology
etd.degree.levelDoctoral
local.academicunitDepartment of Psychology
local.subjectareaPsychology


Files in this item

Thumbnail
This item appears in the following Collection(s)

Show simple item record