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dc.contributor.advisorBoehm, Gary W.
dc.contributor.authorTarr, Andrew Justinen_US
dc.date.accessioned2014-07-22T18:47:49Z
dc.date.available2014-07-22T18:47:49Z
dc.date.created2009en_US
dc.date.issued2009en_US
dc.identifieretd-10302009-115548en_US
dc.identifierumi-10087en_US
dc.identifiercat-001495730en_US
dc.identifier.urihttps://repository.tcu.edu:443/handle/116099117/4198
dc.description.abstractNeurogenesis within the hippocampus along with learning/memory are altered by many factors including stress, immune activation, and depression. Chronic dosing with antidepressants has been shown to alleviate many of the symptoms following immune activation. To examine interactions between depression, immune activation, and cognitive dysfunction more closely, the following experiments were conducted. Generally, the current set of experiments examined the effects that repeated bolus injections of LPS have on spatial learning in MWM, memory consolidation in both CFC and MWM, and hippocampal neurogenesis.^The effects of chronic (all experiments), or acute imipramine (Experiments 3 and 4) were also examined to see if they influenced the hypothesized LPS-induced decrements.^Experiment 1 looked at the effects of chronic imipramine (10mg/kg for 21 days) and 4 bolus injections of LPS (1mg/kg) have on Morris water maze acquisition, and hippocampal neurogenesis after a 3-day break (past the point that central or peripheral cytokines are present). Experiment 2 addressed the effects that chronic imipramine and bolus injections of LPS have on neurogenesis after a 3-day break (i.e., prior to any potential effects of behavioral testing). Experiment 3 examined the effects acute verses chronic imipramine coadministration with a single acute bolus injection of LPS (1mg/kg) on memory consolidation in Morris water maze. Experiment 4 was much like Experiment 3 but instead of MWM, a CFC paradigm was used.^Our hypotheses were that LPS-treated animals would show acquisition deficits in MWM, memory consolidation deficits in both MWM and CFC, and show a decline in neurogenesis (at both the initial and survival timepoints).^Moreover, we hypothesized that chronic but not acute administration of imipramine would ameliorate all decrements in MWM, CFC, and neurogenesis as the result from repeated or acute bolus LPS administration. The data revealed that LPS did not show the hypothesized effects nor did imipramine in all four studies. We attribute our negative findings may be due to endotoxin tolerance, monocytic priming, TLR-4 down-regulation and/or stress from both behavioral testing and repeated injections.en_US
dc.format.mediumFormat: Onlineen_US
dc.language.isoengen_US
dc.publisher[Fort Worth, Tex.] : Texas Christian University,en_US
dc.relation.ispartofTexas Christian University dissertationen_US
dc.relation.ispartofUMI thesis.en_US
dc.relation.ispartofTexas Christian University dissertation.en_US
dc.relation.requiresMode of access: World Wide Web.en_US
dc.relation.requiresSystem requirements: Adobe Acrobat reader.en_US
dc.subject.lcshDevelopmental neurobiology.en_US
dc.subject.lcshMemory.en_US
dc.subject.lcshStress (Psychology) Immunology.en_US
dc.subject.lcshDepression, Mental Immunology.en_US
dc.subject.lcshCytokines.en_US
dc.subject.lcshEndotoxins.en_US
dc.titleEffects of chronic antidepressant coadministration on acquisition, memory consolidation, and neurogenesis after repeated Lipopolysaccharide administrationen_US
dc.typeTexten_US
etd.degree.departmentDepartment of Psychology
etd.degree.levelDoctoral
local.collegeCollege of Science and Engineering
local.departmentPsychology
local.academicunitDepartment of Psychology
dc.type.genreDissertation
local.subjectareaPsychology
etd.degree.nameDoctor of Philosophy
etd.degree.grantorTexas Christian University


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