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dc.contributor.authorWang, Mangjiaen_US
dc.date.accessioned2014-07-22T18:48:47Z
dc.date.available2014-07-22T18:48:47Z
dc.date.created2012en_US
dc.date.issued2012en_US
dc.identifieretd-07312012-142608en_US
dc.identifierumi-10343en_US
dc.identifiercat-001902368en_US
dc.identifier.urihttps://repository.tcu.edu:443/handle/116099117/4438
dc.descriptionTitle from dissertation title page (viewed Dec. 18, 2012).en_US
dc.descriptionIncludes abstract.en_US
dc.descriptionThesis (Ph.D.)--Texas Christian University, 2012.en_US
dc.descriptionDepartment of Chemistry; advisor, Jeffery L. Coffer.en_US
dc.descriptionIncludes bibliographical references.en_US
dc.descriptionText (electronic thesis) in PDF.en_US
dc.descriptionControlled delivery of antibacterial agents remains a topic of widespread significance, given the need for sustained release of therapeutically relevant concentrations. Porous Si (PSi), and the mesoporous form in particular, possesses useful properties relevant to its use in medical therapies such as drug delivery and tissue engineering. For drug delivery, both the biodegradability of mesoporous Si and its ability to nanostructure a given encapsulated substance present marked advantages. In this work we have systematically investigated the influence of the properties of mesoporous silicon on both controlled release and antibacterial assay for the case of the loaded antibacterial drug triclosan and its activity versus Staphylococcus aureus. Specifically, the role of Si porosity, loading method, surface chemistry and particle morphology on the above outcomes are explored.^For long term stabilization of the drug-loaded PSi, preliminary experiments regarding organosilicon and organotitanium surface coatings have also been carried out. The role of PSi porosity on drug delivery has been highlighted by a comparison between the properties of triclosan loaded into porous silicon with high (81%), medium (65-75%), and low porosity (13%). The significant differences in triclosan release behavior are demonstrated in their corresponding antibacterial disk diffusion assays. A remarkable sustained triclosan release beyond 100 days from mesoporous silicon matrices was revealed, combined with an enhanced concentration of released triclosan. Due to the high surface area of these mesoporous materials, surface chemistry is expected to have a significant impact on drug delivery. Since freshly-etched PSi with its hydride-terminated surface possesses a relatively rapid degradation rate in aqueous media, derivatization of PSi by oxidation or chemical modification is needed.^In this study, a relatively long octyl chain is covalently attached to the mesoporous silicon surface, which possesses hydrophobicity and inhibits aqueous dissolution. A combination of thermogravimetric analysis, X-ray diffraction, electron microscopy, and FT IR spectroscopy, in addition to triclosan release and antibacterial assays, are employed for this purpose. A preliminary study involving organosilica and organotitania surface coatings on PSi was also conducted. FT IR spectroscopy, scanning electron microscopy (SEM), energy-dispersive X-ray (EDX) analyses, and subsequent antibacterial assays confirm that the coating is present.en_US
dc.format.mediumFormat: Onlineen_US
dc.language.isoengen_US
dc.publisher[Fort Worth, Tex.] : Texas Christian University,en_US
dc.relation.ispartofTexas Christian University dissertationen_US
dc.relation.ispartofUMI thesis.en_US
dc.relation.ispartofTexas Christian University dissertation.en_US
dc.relation.requiresMode of access: World Wide Web.en_US
dc.relation.requiresSystem requirements: Adobe Acrobat reader.en_US
dc.subject.lcshNanomedicine.en_US
dc.subject.lcshDrug delivery systems.en_US
dc.subject.lcshPorous materials.en_US
dc.subject.lcshNanostructured materials.en_US
dc.subject.lcshSilicon.en_US
dc.titleControlled release of antibacterial compounds based on multiparametric analysis of mesoporous silicon carriers [electronic resource] /en_US
dc.typeTexten_US
etd.degree.departmentDepartment of Chemistry
etd.degree.levelDoctoral
local.academicunitDepartment of Chemistry and Biochemistry
local.subjectareaChemistry and Biochemistry


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