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dc.creatorWhite, Jordon D.
dc.creatorArefin, Tanzil M.
dc.creatorPugliese, Alexa
dc.creatorLee, Choong H.
dc.creatorGassen, Jeff
dc.creatorZhang, Jiangyang
dc.creatorKaffman, Arie
dc.date.accessioned2021-07-08T14:30:50Z
dc.date.available2021-07-08T14:30:50Z
dc.date.issued2020
dc.identifier.urihttps://doi.org/10.7554/eLife.58301
dc.identifier.urihttps://repository.tcu.edu/handle/116099117/47471
dc.identifier.urihttps://elifesciences.org/articles/58301
dc.description.abstractIt is currently unclear whether early life stress (ELS) affects males and females differently. However, a growing body of work has shown that sex moderates responses to stress and injury, with important insights into sex-specific mechanisms provided by work in rodents. Unfortunately, most of the ELS studies in rodents were conducted only in males, a bias that is particularly notable in translational work that has used human imaging. Here we examine the effects of unpredictable postnatal stress (UPS), a mouse model of complex ELS, using high resolution diffusion magnetic resonance imaging. We show that UPS induces several neuroanatomical alterations that were seen in both sexes and resemble those reported in humans. In contrast, exposure to UPS induced fronto-limbic hyper-connectivity in males, but either no change or hypoconnectivity in females. Moderated-mediation analysis found that these sex-specific changes are likely to alter contextual freezing behavior in males but not in females.en_US
dc.language.isoenen_US
dc.publishereLife
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/
dc.sourceeLife
dc.subjectResearch Articleen_US
dc.subjectNeuroscienceen_US
dc.subjectearly life stressen_US
dc.subjectmiceen_US
dc.subjectsexen_US
dc.subjectdiffusion MRIen_US
dc.subjecttractographyen_US
dc.subjectvoxel-based morphometric analysisen_US
dc.titleEarly life stress causes sex-specific changes in adult fronto-limbic connectivity that differentially drive learningen_US
dc.typeArticleen_US
dc.rights.holder2020, White et al
dc.rights.licenseCC BY 4.0
local.collegeCollege of Science and Engineering
local.departmentPsychology
local.personsGassen (PSYC)


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