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dc.contributor.advisorShah, Meena
dc.contributor.advisorWillis, Jada L.
dc.contributor.authorGraybeal, Austin J.en_US
dc.date.accessioned2021-07-29T18:12:30Z
dc.date.available2021-07-29T18:12:30Z
dc.date.created4/28/2021en_US
dc.date.issued4/28/2021en_US
dc.identifiercat-007150583
dc.identifier.urihttps://repository.tcu.edu/handle/116099117/47949
dc.description.abstractAppetite is regulated by perceptions of hunger and fullness and gut hormones that are either anorexigenic such as glucagon-like peptide 1 (GLP-1), cholecystokinin, or peptide YY, or orexigenic such as ghrelin. Appetite suppression may lead to a number of negative effects including relative energy deficiency which impairs health and performance in athletes. Appetite stimulation, on the other hand, may lead to a positive energy balance and weight gain which are associated with many chronic diseases. A number of factors affect appetite regulation. In this dissertation, we examined the effects of varying amounts of dietary carbohydrate and fat and the different types of fatty acids on appetite. We also examined the role of fat-free body mass in appetite regulation. It is unclear whether different fatty acids vary in their effects on appetite and eating in the absence of hunger. In our first study, we examined the effects of three high-fat meals rich in either monounsaturated, polyunsaturated, or saturated fatty acids on subjective ratings of appetite and subsequent ad libitum lunch consumption in healthy premenopausal normal-weight women in a randomized cross-over single-blind study. We found that postprandial ratings of hunger, fullness, or desire to eat did not vary across meal conditions. There was also no difference in energy intake during the ad libitum lunch across meal conditions. Many endurance athletes follow a ketogenic diet (KD) (very low in carbohydrate and high in fat) to improve performance. The effect of a KD on appetite remains unclear in this population. In our second study, we examined the effects of a KD on fasting measures of appetite in highly-trained cyclists and triathletes. The participants consumed both a KD and a high-carbohydrate diet (HCD), for two weeks each, in a random order, after their habitual diet (HD). We also assessed postprandial appetite measures in response to a ketogenic meal after the KD, a high-carbohydrate meal after the HCD, and a standard American/Western meal after the HD. The results showed that the KD led to significantly higher fasting GLP-1 and lower ghrelin concentrations compared to the HCD and HD. The ketogenic meal also led to significantly higher postprandial GLP-1 and lower ghrelin levels compared to the high-carbohydrate and standard meals. Results on appetite perceptions did not match the hormonal changes and needs further evaluation. Energy homeostasis is defined as the maintenance of body energy stores over time. To maintain these energy stores, appetite responds to changes in body mass by stimulating or suppressing food intake. It is well known that fat mass possesses a level of physiological regulation over appetite but the influence of fat-free mass in physiological appetite regulation is unclear. In our final manuscript, we discussed in detail the potential relationship between fat-free mass and hunger and satiety hormone production. From this paper, we concluded that there is an association between fat-free mass (FFM) and appetite-related hormones. Specifically, higher FFM may be linked to decreases in the orexigenic hormone, ghrelin. Clinicians and dietary professionals should emphasize strategies that focus on the maintenance or increase of FFM to regulate appetite. In conclusion, a very low-carbohydrate high-fat diet versus diets with more carbohydrate and less fat led to more anorexigenic alterations in the objective measures of appetite. These changes were not matched by the subjective measures of appetite. More research is necessary to determine the reasons for these differences. The type of fat in a high-fat meal did not affect perception of appetite or future energy consumption. Fat-free mass may have a role in appetite regulation but requires further study.
dc.format.mediumFormat: Onlineen_US
dc.language.isoenen_US
dc.subjectKinesiologyen_US
dc.subjectNutritionen_US
dc.subjectObstetricsen_US
dc.subjectAppetiteen_US
dc.subjectEndurance athletesen_US
dc.subjectFat-free massen_US
dc.subjectFatty acidsen_US
dc.subjectHigh-carbohydrate dieten_US
dc.subjectKetogenic dieten_US
dc.titleThe Role of Diet Composition and Fat-Free Mass on Appetite Regulationen_US
dc.typeTexten_US
etd.degree.departmentDepartment of Kinesiology
etd.degree.levelDoctoral
local.collegeHarris College of Nursing and Health Sciences
local.departmentKinesiology
local.academicunitHarris College of Nursing and Health Sciences
dc.type.genreDissertation
local.subjectareaKinesiology
etd.degree.nameDoctor of Philosophy
etd.degree.grantorTexas Christian University


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