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dc.contributor.advisorMcGillivray, Shauna M.
dc.contributor.authorHuang, Yueyangen_US
dc.date.accessioned2015-08-10T18:20:45Z
dc.date.available2015-08-10T18:20:45Z
dc.date.created2015en_US
dc.date.issued2015en_US
dc.identifierUMI thesisen_US
dc.identifier.urihttps://repository.tcu.edu/handle/116099117/8636
dc.description.abstractStaphylococcus aureus quickly develops resistance to antibiotics and poses a significant health threat to humans. New antibiotic targets are needed for the development of new antibiotics. Trans-translation has important roles in maintaining bacterial viability. Small molecules, KKL-35 and KKL-40, were recently identified as specific inhibitors of trans-translation. We have investigated the roles of trans-translation on S. aureus viability and the potential of KKL-35 and KKL-40 as antibiotics. We find that KKLs show bactericidal activity against multiple S. aureus strains at relatively low concentration. We also find that sub-lethal doses of KKLs make S. aureus more susceptible to antimicrobials. Neither KKL-35 nor KKL-40 are cytotoxic to human HeLa cells. Unfortunately, KKL-40 is inactivated by human serum. Therefore, new inhibitors will need to be identified in future studies. Notably, the development of resistance by S.aureus against KKLs remains at a low level. Therefore trans-translation is a promising target for antibiotic development.en_US
dc.format.mediumFormat: Onlineen_US
dc.publisher[Fort Worth, Tex.] : Texas Christian University,en_US
dc.relation.ispartofTCU Master Thesisen_US
dc.relation.requiresMode of access: World Wide Web.en_US
dc.relation.requiresSystem requirements: Adobe Acrobat reader.en_US
dc.titleSmall molecule inhibition of trans-translation impairs Staphylococcus aureus viabilityen_US
dc.typeTexten_US
etd.degree.levelMaster
local.collegeCollege of Science and Engineering
local.departmentBiology
local.academicunitDepartment of Biology
dc.type.genreThesis
local.subjectareaBiology
etd.degree.nameMaster of Science


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