dc.contributor.advisor | McGillivray, Shauna M. | |
dc.contributor.author | Huang, Yueyang | en_US |
dc.date.accessioned | 2015-08-10T18:20:45Z | |
dc.date.available | 2015-08-10T18:20:45Z | |
dc.date.created | 2015 | en_US |
dc.date.issued | 2015 | en_US |
dc.identifier | UMI thesis | en_US |
dc.identifier | cat-2403544 | en_US |
dc.identifier.uri | https://repository.tcu.edu/handle/116099117/8636 | |
dc.description.abstract | Staphylococcus aureus quickly develops resistance to antibiotics and poses a significant health threat to humans. New antibiotic targets are needed for the development of new antibiotics. Trans-translation has important roles in maintaining bacterial viability. Small molecules, KKL-35 and KKL-40, were recently identified as specific inhibitors of trans-translation. We have investigated the roles of trans-translation on S. aureus viability and the potential of KKL-35 and KKL-40 as antibiotics. We find that KKLs show bactericidal activity against multiple S. aureus strains at relatively low concentration. We also find that sub-lethal doses of KKLs make S. aureus more susceptible to antimicrobials. Neither KKL-35 nor KKL-40 are cytotoxic to human HeLa cells. Unfortunately, KKL-40 is inactivated by human serum. Therefore, new inhibitors will need to be identified in future studies. Notably, the development of resistance by S.aureus against KKLs remains at a low level. Therefore trans-translation is a promising target for antibiotic development. | en_US |
dc.format.medium | Format: Online | en_US |
dc.publisher | [Fort Worth, Tex.] : Texas Christian University, | en_US |
dc.relation.ispartof | TCU Master Thesis | en_US |
dc.relation.requires | Mode of access: World Wide Web. | en_US |
dc.relation.requires | System requirements: Adobe Acrobat reader. | en_US |
dc.title | Small molecule inhibition of trans-translation impairs Staphylococcus aureus viability | en_US |
dc.type | Text | en_US |
etd.degree.level | Master | |
local.college | College of Science and Engineering | |
local.department | Biology | |
local.academicunit | Department of Biology | |
dc.type.genre | Thesis | |
local.subjectarea | Biology | |
etd.degree.name | Master of Science | |