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dc.contributor.authorWhite, Jordon Danielleen_US
dc.date.accessioned2015-08-10T18:20:50Z
dc.date.available2015-08-10T18:20:50Z
dc.date.created2015.en_US
dc.date.created2015en_US
dc.date.issued2015en_US
dc.identifierTCU Master Thesisen_US
dc.identifier.urihttps://repository.tcu.edu/handle/116099117/8646
dc.descriptionTitle from thesis title page (viewed Aug. 19, 2015).en_US
dc.descriptionIncludes abstract.en_US
dc.descriptionThesis--Texas Christian University, 2015.en_US
dc.descriptionDepartment of Psychology; advisor: Gary W. Boehm.en_US
dc.descriptionIncludes bibliographical references.en_US
dc.descriptionText (electronic thesis) in PDF.en_US
dc.description.abstractAlzheimers disease (AD) is characterized by the formation of amyloid-beta (A?) plaques and neurofibrillary tangles; inflammation has been implicated in this process. Our previous work resulted in an animal model of AD-like pathology using the bacterial endotoxin lipopolysaccharide (LPS). Following 7 consecutive injections of LPS, mice have significantly elevated levels of A? with deficits in spatial cognition, but A? levels are decreased following 2 weeks of voluntary exercise. We explored whether exercise could rescue cognitive function and alter microglial phenotypes to decrease A? load. We found that at 2 weeks, there were no cognitive deficits present, but that exercise could enhance performance regardless of previous LPS or saline treatment. These gains were accompanied by modest increases in BDNF, whereas increases in IL-4 mRNA expression were not found. Exercise had no effect on the fluorescence of microglial phenotype marker, arginase, while LPS-administration appeared to increase arginase expression over saline controls.--Abstract.en_US
dc.format.mediumFormat: Onlineen_US
dc.publisher[Fort Worth, Tex.] : Texas Christian University,en_US
dc.relation.ispartofUMI thesis.en_US
dc.relation.requiresMode of access: World Wide Web.en_US
dc.relation.requiresSystem requirements: Adobe Acrobat reader.en_US
dc.titleExercise and microglial cell activation [electronic resource] /en_US
dc.typeTexten_US
local.academicunitDepartment of Psychology
local.subjectareaPsychology


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