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Role of the pathway from the basolateral amygdala to the nucleus accumbens on recovery from frustration
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2025-11-19
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Unexpected reductions in reward typically induce a transient negative emotional state known as frustration, characterized by behavioral suppression and conflict between approach and avoidance. The present study examined whether the projection from the basolateral amygdala (BLA) to the nucleus accumbens (NAc) contributes to recovery from consummatory suppression after a reward downshift. Using a double viral strategy, Cre-dependent excitatory or inhibitory DREADDs were expressed in BLA neurons projecting to the NAc. Rats were trained to consume 32% sucrose and later exposed to a downshift to 2% sucrose, generating a frustration response. Inhibition of the BLA→NAc pathway delayed recovery of normal licking behavior across postshift sessions, suggesting a prolonged impact of reward loss. This effect was not attributable to locomotor deficits. Effects of pathway excitation remain unclear due to inconsistent activity outcomes. These results indicate that the BLA→NAc projection facilitates behavioral recovery following violations of reward expectation.
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Psychology