2023-02-272023-02-272022https://repository.tcu.edu/handle/116099117/57382A series of P-stereogenic chiral phosphorus acids (CPAs) were synthesized to determine the requirements for efficient asymmetric organocatalysis. In order to eliminate the need for C2-symmetry in common CPAs, various scaffolds containing C1-symmetrical thiophosphorus acids were chosen. These new compounds were synthesized and evaluated in the asymmetric transfer hydrogenation of 2-phenylquinoline. Although the efficacy of the thiophosphorus acids was disappointing for this reaction, the work should be useful for developing structural design elements.asymmetricheterocyclesorganocatalysisphosphorussynthesisArticleCC BY 4.0https://doi.org/10.3762/bjoc.18.154