2016-08-032016-08-032016-07-13https://repository.tcu.edu/handle/116099117/11211https://pubs.rsc.org/en/Content/ArticleLanding/2016/OB/C6OB01413EEasily prepared menthyl phosphinates of high diastereoisomeric purity provide versatile intermediates for the synthesis of P-stereogenic compounds. Previous efforts starting about fifty years ago have been hampered by a lack of generality so the menthyl route has been nearly abandoned. Herein we provide a general solution to this long-standing problem and describe a general synthesis of menthyl H-phosphinate and disubstituted phosphinate esters. The method to prepare these versatile precursors relies on a simple and inexpensive process avoiding the use of phosphorus trichloride, Grignard reagents, and complicated cryogenic crystallizations. Established protocols can then be employed to synthesize P-stereogenic secondary and tertiary phosphine oxides and therefore P-stereogenic phosphine ligands.enhttps://creativecommons.org/licenses/by/3.0/Catalyzed dehydrative allylationasymmetric-synthesisabsolute-configurationstereospecific reductionhypophosphorous acidH-phosphinatestereocontrolled synthesisstereoselective-synthesisdiphenylphosphine oxidechiral phosphorusArticleCC BY 3.0https://doi.org/10.1039/C6OB01413E