Interaction of BODIPY dyes with bovine serum albumin: a case study on the aggregation of a click-BODIPY dye

Jameson, Laramie P.; Smith, Nicholas W.; Annunziata, Onofrio; Dzyuba, Sergei V.

Publication

Interaction of BODIPY dyes with bovine serum albumin: a case study on the aggregation of a click-BODIPY dye

Jameson, Laramie P.; Smith, Nicholas W.; Annunziata, Onofrio; Dzyuba, Sergei V.

Publisher

The Royal Society of Chemistry

Date

2016-05-09

Abstract

The fluorescence of BODIPY and click-BODIPY dyes was found to substantially increase in the presence of bovine serum albumin (BSA). BSA acted as a solubilizer for dye aggregates, in addition to being a conventional binding scaffold for the click-BODIPY dyes, indicating that disaggregation of fluorophores should be considered when evaluating dye-protein interactions.