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Localizing the Epileptogenic Zone with Novel Biomarkers
Papadelis, Christos Perry, M. Scott
Papadelis, Christos
Perry, M. Scott
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Publisher
W B Saunders Co-Elsevier Inc
Date
2021
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Abstract
Several noninvasive methods, such as high-density EEG or magnetoencephalography, are currently used to delineate the epileptogenic zone (EZ) during the presurgical evaluation of patients with drug resistant epilepsy (DRE). Yet, none of these methods can reliably identify the EZ by their own. In most cases a multimodal approach is needed. Challenging cases often require the implantation of intracranial electrodes, either through stereo-taxic EEG or electro-corticography. Recently, a growing body of literature introduces novel biomarkers of epilepsy that can be used for analyzing both invasive as well as noninvasive electrophysiological data. Some of these biomarkers are able to delineate the EZ with high precision, augment the presurgical evaluation, and predict the surgical outcome of patients with DRE undergoing surgery. However, the use of these epilepsy biomarkers in clinical practice is limited. Here, we summarize and discuss the latest technological advances in the presurgical neurophysiological evaluation of children with DRE with emphasis on electric and magnetic source imaging, high frequency oscillations, and functional connectivity.
Contents
Subject
High-Frequency Oscillations
Epilepsy Surgery
Temporal-Lobe
Functional Connectivity
Presurgical Evaluation
Clinical Utility
Scalp Eeg
Seizure
Localization
Children
Epilepsy Surgery
Temporal-Lobe
Functional Connectivity
Presurgical Evaluation
Clinical Utility
Scalp Eeg
Seizure
Localization
Children
Subject(s)
Research Projects
Organizational Units
Journal Issue
Genre
Description
Format
Department
Burnett School of Medicine