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Design, synthesis, and evaluation of chiral thiophosphorus acids as organocatalysts
Winters, Karen R Montchamp, Jean-Luc
Winters, Karen R
Montchamp, Jean-Luc
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Beilstein Institut
Date
2022
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Abstract
A series of P-stereogenic chiral phosphorus acids (CPAs) were synthesized to determine the requirements for efficient asymmetric organocatalysis. In order to eliminate the need for C2-symmetry in common CPAs, various scaffolds containing C1-symmetrical thiophosphorus acids were chosen. These new compounds were synthesized and evaluated in the asymmetric transfer hydrogenation of 2-phenylquinoline. Although the efficacy of the thiophosphorus acids was disappointing for this reaction, the work should be useful for developing structural design elements.
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Subject
asymmetric
heterocycles
organocatalysis
phosphorus
synthesis
heterocycles
organocatalysis
phosphorus
synthesis
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Chemistry and Biochemistry