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Deficits in memory consolidation induced by bacterial endotoxin in mice coincide with elevated cytokine and chemokine levels, but diminished expression of brain-derived neurotrophic factor
Kranjac, Dinko
Kranjac, Dinko
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[Fort Worth, Tex.] : Texas Christian University,
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2011
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Lipopolysaccharide induces the synthesis and release of pro-inflammatory cytokines and chemokines in the periphery and the central nervous system. It has previously been reported that peripheral LPS administration in rats disrupts contextual fear memory consolidation processes, potentially due to elevated cytokine expression. We used a similar, but predominantly olfactory based, paradigm to characterize the behavioral effects of LPS administration in mice. As hypothesized, LPS administered immediately or 2 h, but not 12 h, post-training impaired memory consolidation processes that support the storage of the conditioned contextual fear memory. Consistent with the behavioral findings, 4 h post-injection, cytokine and chemokine levels were heightened in LPS-treated animals, with a simultaneous decrease in brain-derived neurotrophic factor (BDNF) mRNA. Collectively, these data reinforce and extend prior work, and suggest that contextual fear conditioning, with the addition of olfactory cues, offers a promising way to study cognitive deficits induced by peripheral immune activation in mice.
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Psychology