Loading...
Calcified Nanostructured Silicon Wafer Surfaces for Biosensing: Effects of Surface Modification on Bioactivity
Weis, Robert P. Montchamp, Jean-Luc Coffer, Jeffery L. Gamal Attiah, Darlene Desai, Tejal A.
Weis, Robert P.
Montchamp, Jean-Luc
Coffer, Jeffery L.
Gamal Attiah, Darlene
Desai, Tejal A.
Citations
Altmetric:
Soloist
Composer
Publisher
Hindawi
Date
2003-02-12
Additional date(s)
Abstract
The growth of known biologically-relevant mineral phases on semiconducting surfaces is one strategy to explicitly induce bioactivity in such materials, either for sensing or drug delivery applications. In this work, we describe the use of a spark ablation process to fabricate deliberate patterns of Ca10(PO4)6(OH)2 on crystalline Si (calcified nanoporous silicon). These patterns have been principally characterized by scanning electron microscopy in conjunction with elemental characterization by energy dispersive x-ray analysis. This is followed by a detailed comparison of the effects of fibroblast adhesion and proliferation onto calcified nanoporous Si, calcified nanoporous Si derivatized with alendronate, as well as control samples of an identical surface area containing porous SiO2. Fibroblast adhesion and proliferation assays demonstrate that a higher density of cells grow on the Ca3(PO4)2 /porous Si/ SiO2 structures relative to the alendronate-modified surfaces and porous Si/SiOM2 samples.
Contents
Subject
Calcium phosphate
silicon
fibroblasts
biosensor
silicon
fibroblasts
biosensor
Subject(s)
Research Projects
Organizational Units
Journal Issue
Genre
Description
Format
Department
Chemistry and Biochemistry