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Role of the NMDA receptor in consummatory successive negative contrast
Norris, Jacob N
Norris, Jacob N
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[Fort Worth, Tex.] : Texas Christian University,
Date
2009
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Abstract
Four experiments using the partial agonist D-cycloserine (DCS) were conducted to investigate the role of the N-methyl D-aspartate (NMDA) receptor in consummatory successive negative contrast (cSNC), an animal model of loss-induced anxiety. . In Experiment 1, pretrial 11 and 12 administration of DCS (30 mg/kg) enhanced cSNC following the reward downshift from 32%-to-4% sucrose solution. In Experiment 2, posttrial 11 administration of DCS enhanced cSNC greatest at 30 mg/kg, following 32%-to-4%, and mildly following 32%-to-6%. In Experiment 3, DCS at 15 mg/kg and 60 mg/kg prolonged cSNC mildly (32%-to-4%). Experiment 4 suggested enhancement was not the result of conditioned taste aversion (CTA) to DCS (30 mg/kg); CTA to novel 4% solution failed to develop, compared to unpaired and saline controls. Results were interpreted to mean that activation of NMDA receptors via the glycine-modulatory site enhances the aversive memory associated with unexpected reward loss. Possible applications for therapeutic settings are discussed.
Contents
Subject
Subject(s)
Methyl aspartate Receptors.
Anxiety.
Memory.
Fear Physiological aspects.
Anxiety.
Memory.
Fear Physiological aspects.
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Dissertation
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Department
Psychology