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Developoment of cardiovascular and neurodevelopmental metrics as sublethal endpoints for the fish embryo toxicity test
Krzykwa, Julie Christina
Krzykwa, Julie Christina
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2017
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The United States requires whole effluent and chemicals be tested for aquatic toxicity using the fathead minnow larval growth and survival test. The fathead minnow fish embryo toxicity (FET) test has been proposed as a more humane alternative, but its utility is limited as it currently does not allow for the prediction of non-lethal adverse outcomes. This study investigated sublethal endpoints related to cardiovascular function and development (e.g., heart rate and pericardial area), neurodevelopment (e.g., eye development and activity levels) and growth (e.g., length and mass), as additional FET test metrics. Tests were run with four model toxicants: 3,4–dichloroaniline, sodium chloride, cadmium chloride, and triclosan. Toxicant-induced alterations in pericardial area, eye size, and body length suggest that these sublethal endpoints may be useful for estimating non-lethal adverse effects. Future studies aimed at linking alterations in these endpoints to longer term adverse impacts are needed.
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1 online resource (vi, 53 pages) :
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Biology