Infusions of cholecystokinin-octapeptide into the ventral tegmental area enhance the reinforcing effects of amphetamine
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Date
1987
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Abstract
The objectives of the present study were to behaviorally and neurochemically investigate reinforcing properties of the neuropeptide cholecystokinin (CCK) in the ventral tegmental area (VTA). CCK infusions into the VTA significantly potentiated the reinforcing effects of amphetamine. CCK did not, by itself, have reinforcing or aversive effects at any dose tested (0.0, 0.04. 0.4 and 4.0 nanograms/cannula). Furthermore, infusions of CCK into the VTA did not significantly affect basal or amphetamine-enhanced depletion of DA in caudate or in three regions of the N ACC following administration of a tyrosine hydroxylase inhibitor. Results of the present dissertation indicate that (1) CCK may functionally interact with dopaminergic mechanisms in facilatory manners which do not enhance DA release and (2) that sites of action for CCK may exist in the VTA.
Contents
Subject
Subject(s)
Cholecystokinin
Amphetamines
Amphetamines
Research Projects
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Genre
Dissertation
Description
Format
viii, 93 leaves, bound : illustrations
Department
Psychology