Loading...
Separation Of Menthyl (Hydroxymethyl)-Phenyl Phosphinate Using Molecularly Imprinted Polymers
Hancock, Kari
Hancock, Kari
Citations
Altmetric:
Soloist
Composer
Publisher
Date
2017
Additional date(s)
2017-05-19
Abstract
Molecularly imprinted polymers (MIPs) are advantageous to chemists both in their ability to drive the equilibrium of a reaction toward a desired product and in chromatography. In this project we focused on the use of MIPs in a chromatographic sense to selectively isolate menthyl (hydroxymethyl)-phenyl phosphinate in the SP form from a mixture of both diastereoisomers. Both RP and SP configurations are made in equal proportions but the yield from isolation and crystallization of each pure diastereoisomer is ~25%. Production of a polymer containing pockets specific to the configuration of one diastereoisomer enables an easier method to isolate one diastereoisomer through absorption by the polymer and subsequent release. The potential for MIPs for these P-stereogenic compounds lies in the increased yield of pure crystals and therefore decreased cost of production.
Contents
Subject
Subject(s)
Research Projects
Organizational Units
Journal Issue
Genre
Description
Format
Department
Chemistry and Biochemistry