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dc.creatorGonzalez-Rodriguez, Roberto
dc.creatorGranitzer, Petra
dc.creatorRumpf, Klemens
dc.creatorCoffer, Jeffery L.
dc.description.abstractThis article describes the preparation and fundamental properties of a new possible material as a magnetic resonance imaging contrast agent based on the incorporation of preformed iron oxide (Fe3O4) nanocrystals into hollow silicon nanotubes (Si NTs). Specifically, superparamagnetic Fe3O4 nanoparticles of two different average sizes (5 nm and 8 nm) were loaded into Si NTs of two different shell thicknesses (40 nm and 70 nm). To achieve proper aqueous solubility, the NTs were functionalized with an outer polyethylene glycol-diacid (600) moiety via an aminopropyl linkage. Relaxometry parameters r1 and r2 were measured, with the corresponding r2/r1 ratios in phosphate buffered saline confirming the expected negative contrast agent behaviour for these materials. For a given nanocrystal size, the observed r2 values are found to be inversely proportional to NT wall thickness, thereby demonstrating the role of nanostructured silicon template on associated relaxometry properties.en_US
dc.publisherThe Royal Society
dc.sourceRoyal Society Open Science
dc.subjectsilicon nanotubesen_US
dc.subjectiron oxideen_US
dc.subjectMRI contrast agenten_US
dc.titleNew MRI contrast agents based on silicon nanotubes loaded with superparamagnetic iron oxide nanoparticlesen_US
dc.rights.holderGonzalez-Rodriguez et al.
dc.rights.licenseCC BY 4.0
local.collegeCollege of Science and Engineering
local.departmentChemistry & Biochemistry
local.personsGonzalez-Rodriguez, Coffer (CHEM)

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