Public Interest in Acetyl Hexapeptide-8: Longitudinal Analysis
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2024-02-20
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acetyl-hexapeptide-8
anti-aging
anti-wrinkle
Argireline
BoNT
botox
botulinum neurotoxin
cosmetic dermatology
cosmetic
dermatologist
dermatology
injectable neurotoxin
neurotoxin
skin specialist
topical agent
topical
anti-aging
anti-wrinkle
Argireline
BoNT
botox
botulinum neurotoxin
cosmetic dermatology
cosmetic
dermatologist
dermatology
injectable neurotoxin
neurotoxin
skin specialist
topical agent
topical
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Description
Background: Acetyl hexapeptide-8, also known as Argireline, is a topical, short-acting, synthetic peptide that has recently gained popularity for its antiwrinkle effects. This agent has emerged as a more accessible alternative to botulinum neurotoxin. Objective: This study evaluates the public interest in acetyl hexapeptide-8 in the United States from 2013 to 2023, as described by search volume on Google, the most-used search engine. Methods: We analyzed the longitudinal relative monthly search volume from January 1, 2013, to January 1, 2023, for acetyl hexapeptide–related terms. We compared the internet search trends for “Botox” during this period to “Argireline.” Results: The terms “Argireline” and “Botox in a Bottle” both had substantial increases in search volume in 2022. Although its search volume is drastically increasing, “Argireline” was less searched than “Botox,” which had a stable, up-trending search volume over the past decade. Conclusions: The increasing interest in acetyl hexapeptide-8 may be due to its cost-effectiveness and use as a botulinum neurotoxin alternative. Affordability, over-the-counter availability, and ease of self-application of the agent suggest its potential to enhance accessibility to cosmetic dermatologic care.