The impact of person-based factors on vagus nerve stimulation intensity and responsiveness
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2025-04-24
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Transcutaneous auricular vagus nerve stimulation (taVNS) is a therapy used to treat conditions like epilepsy and treatment-resistant depression. TaVNS works by stimulating the afferent fibers of the vagus nerve, activating the central nervous system. This study examines person-based factors, such as sex, childhood experiences, and body awareness, that influence one's response to stimulation. Specifically, we will assess (a) sensitivity to taVNS intensity, or the current in milliamps that is applied transcutaneously at the tragus, and (b) responsiveness to stimulation, measured by neurocardiac response, or change in heart rate variability (HRV) from baseline to stimulation, while controlling for intensity. Results revealed greater VNS responsiveness in individuals with lower vagal tone, lower childhood SES, higher childhood unpredictability, and higher ACES score. Several of these effects were driven by female participants. Future research should examine whether this translates to clinical efficacy, and evaluate whether it can be utilized to prevent certain conditions.
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Psychology