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The Relationship of UGT2B15 Pharmacogenetics and Lorazepam for Anxiety
Ching N. R. Alzghari A. K. Alzghari S. K.
Ching N. R.
Alzghari A. K.
Alzghari S. K.
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Cureus
Date
2018-08-13
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Abstract
Anxiety affects over 260 million people worldwide. Benzodiazepines are a class of agents used in combination with other therapies for the management of anxiety. Lorazepam is a commonly prescribed benzodiazepine metabolized by uridine 5'-diphosphate-glucuronosyltransferases. Herein, we discuss recent findings regarding the pharmacogenetics of uridine 5'-diphosphate-glucuronosyltransferase 2B15 (UGT2B15), lorazepam, and its role in the treatment of anxiety.
Contents
Subject
lorazepam
single nucleotide polymorphisms
anxiety
pharmacogenetics
ugt2b15
single nucleotide polymorphisms
anxiety
pharmacogenetics
ugt2b15
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Department
Chemistry and Biochemistry