Loading...
Novel Form of Curcumin Improves Endothelial Function in Young, Healthy Individuals: A Double-Blind Placebo Controlled Study
Citations
Altmetric:
Soloist
Composer
Publisher
Hindawi
Date
2016-08-17
Additional date(s)
Abstract
Curcumin, a turmeric extract, may protect against cardiovascular diseases by enhancing endothelial function. In this randomized controlled double-blind parallel prospective study, fifty-nine healthy adults were assigned to placebo, 50mg (50mg), or 200mg (200mg) curcumin, for 8 weeks. The higher curcumin (200mg) supplementation produced a dose-mediated improvement in endothelial function measured by flow-mediated dilation (FMD). The outcome was a clinically substantial 3.0% increase (90% CI 0.7 to 5.3%, ; benefit : harm odds ratio 546:1) with the 200mg dose, relative to placebo. The 50mg dose also increased FMD relative to placebo by 1.7% (-0.6 to 4.0%, ; 25:1), but the outcome was not clinically decisive. In apparently healthy adults, 8 weeks of 200mg oral curcumin supplementation resulted in a clinically meaningful improvement in endothelial function as measured by FMD. Oral curcumin supplementation may present a simple lifestyle strategy for decreasing the risk of cardiovascular diseases. This trial was registered at ISRCTN registry (ISRCTN90184217).
Contents
Subject(s)
Research Projects
Organizational Units
Journal Issue
Genre
Description
Format
Department
Kinesiology