On June 23, 2016, the United Kingdom voted to leave the European Union. This project aims to answer the question of why Leave was more popular in some regions and Remain in others. Past research has divided the reasons into two camps: economic and cultural. In order to answer this question, this paper conducts a hybrid study. First, there is a quantitative aspect where bivariate relationships are established between various variables and the vote to leave the European Union, aggregated by region. Second, the paper conducts case studies on the following regions: London, the West Midlands, and Scotland. While the quantitative aspect presents a story that excludes the economic argument, the case studies indicate that the reasoning is much more complex. Once the reasons for success of the ?Leave? vote are understood, policymakers can better address the underlying needs of the different regions and prepare the country for its exit from the European Union.