| Abstract | Reactive Oxygen Species (ROS) have been shown to play a key role in the development of Alzheimer's disease symptoms and pathology. This ROS production can occur through a variety of natural mechanisms but has also been shown to increase with increasing amyloid-beta plaque formation in the brain of patients with Alzheimer's disease. In this paper, we established a mechanism for measuring ROS production in two cell lines, HT-22 and FRDA cells, as well as tested a variety of compounds, most notably, our novel compound PK60, for their effects on ROS production and cell viability in this cell lines. Our data showed that contrary to our hypothesis, PK60 did not show significant antioxidant capabilities in vitro. |
