The data-collection on adverse effects of anti-HIV drugs (D:A:D) model for predicting cardiovascular events: External validation in a diverse cohort of people living with HIVShow full item record
Title | The data-collection on adverse effects of anti-HIV drugs (D:A:D) model for predicting cardiovascular events: External validation in a diverse cohort of people living with HIV |
---|---|
Author | Anikpo, Ifedioranma; Agovi, Afiba Manza-A.; Cvitanovich, Matthew J.; Lonergan, Frank; Johnson, Marc; Ojha, Rohit P. |
Date | 2021 |
Abstract | Objectives Little is known about the external validity of the Data-collection on Adverse Effects of Anti-HIV Drugs (D:A:D) model for predicting cardiovascular disease (CVD) risk among people living with HIV (PLWH). We aimed to evaluate the performance of the updated D:A:D model for 5-year CVD risk in a diverse group of PLWH engaged in HIV care. Methods We used data from an institutional HIV registry, which includes PLWH engaged in care at a safety-net HIV clinic. Eligible individuals had a baseline clinical encounter between 1 January 2013 and 31 December 2014, with follow-up through to 31 December 2019. We estimated 5-year predicted risks of CVD as a function of the prognostic index and baseline survival of the D:A:D model, which were used to assess model discrimination (C-index), calibration and net benefit. Results Our evaluable population comprised 1029 PLWH, of whom 30% were female, 50% were non-Hispanic black, and median age was 45 years. The C-index was 0.70 [95% confidence limits (CL): 0.64-0.75]. The predicted 5-year CVD risk was 3.0% and the observed 5-year risk was 8.9% (expected/observed ratio = 0.33, 95% CL: 0.26-0.54). The model had a greater net benefit than treating all or treating none at a risk threshold of 10%. Conclusions The D:A:D model was miscalibrated for CVD risk among PLWH engaged in HIV care at an urban safety-net HIV clinic, which may be related to differences in case-mix and baseline CVD risk. Nevertheless, the HIV D:A:D model may be useful for decisions about CVD intervention for high-risk patients. |
Link | https://doi.org/10.1111/hiv.13147
https://onlinelibrary.wiley.com/doi/10.1111/hiv.13147 https://repository.tcu.edu/handle/116099117/49913 |
Department | Medical Education |
Subject | cardiovascular disease
clinical epidemiology external validation HIV prediction model |
Files in this item
- Name:
- HIV Medicine - 2021 - Anikpo - ...
- Size:
- 259.0Kb
- Format:
- Description:
- Main article
This item appears in the following Collection(s)
- Research Publications [481]
Related items
Showing a few items related by title, author, creator and subject.
-
Individuals motivated to participate in adherence, care and treatment (imPACT): development of a multi-component intervention to help HIV-infected recently incarcerated individuals link and adhere to HIV care
Golin, Carol E.; Knight, Kevin; Carda-Auten, Jessica; Gould, Michele; Groves, Jennifer; White, Becky L.; Bradley-Bull, Steve; Amola, Kemi; Fray, Niasha; Rosen, David L.; Mugavaro, Michael J.; Pence, Brian W.; Flynn, Patrick M.; Wohl, David (2016-09-06)Background: Policy-makers promote a seek, test, treat and retain (STTR) strategy to expand HIV testing, support linkage and engagement in care, and enhance the continuous use of antiretroviral therapy for those HIV-infected. ... -
Understanding the sustainability of implementing HIV services in criminal justice settings
Visher, Christy A.; Yang, Yang; Mitchell, Shannon G.; Patterson, Yvonne; Swan, Holly; Pankow, Jennifer (2015-03-07)In the growing field of implementation science, sustainability is a critical component of the implementation process of moving evidence-based treatments to regular practice. This paper is intended to extend our understanding ... -
The Feasibility of Interventions to Reduce HIV Risk and Drug Use among Heterosexual Methamphetamine Users
Corsi, Karen F.; Lehman, Wayne E. K.; Min, Sung-Joon; Lance, Shannon P.; Speer, Nicole; Booth, Robert E.; Shoptaw, Steve (2012-06-04)This paper reports on a feasibility study that examined contingency management among out-of-treatment, heterosexual methamphetamine users and the reduction of drug use and HIV risk. Fifty-eight ...
© TCU Library 2015 | Contact Special Collections |
HTML Sitemap