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Title | The mechanistic basis linking cytokine storm to thrombosis in COVID-19 |
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Author | Wolf A.; Khimani F.; Yoon B.; Gerhart C.; Endsley D.; Ray A.K.; Yango A.F.; Flynn S.D.; Lip G.Y.H.; Gonzalez S.A.; Sathyamoorthy M. |
Date | 2022 |
Abstract | It is now well established that infection with SARS-CoV-2 resulting in COVID-19 disease includes a severely symptomatic subset of patients in whom an aggressive and/or dysregulated host immune response leads to cytokine storm syndrome (CSS) that may be further complicated by thrombotic events, contributing to the severe morbidity and mortality observed in COVID-19. This review provides a brief overview of cytokine storm in COVID-19, and then presents a mechanistic discussion of how cytokine storm affects integrated pathways in thrombosis involving the endothelium, platelets, the coagulation cascade, eicosanoids, auto-antibody mediated thrombosis, and the fibrinolytic system. © 2022 The Authors |
Link | https://doi.org/10.1016/j.tru.2022.100110
https://repository.tcu.edu/handle/116099117/55824 |
Department | Burnett School of Medicine |
Subject | Clots
Coagulopathy COVID-19 Cytokine storm SARS-CoV2 Thrombosis |