| Abstract | Epidemiologic evidence suggests that antibiotic frequency increases insulin resistance and reduces glucose control. However, interventional human studies have produced conflicting results on the effects of short-term antibiotic cycles on glucose control, demonstrating either no effect or harmful effects on glucose control. Our study aimed to contribute to the current body of literature examining the effects of short-term antibiotic cycles on glucose control in order to better clarify and understand the accumulated exposure risk of chronic insulin resistance and glucose dysregulation. Despite a small sample size (n=11), a short antibiotic cycle (3 days of therapeutic dosge of Vancomycin) significantly increased serum fasting insulin (p=0.037) and fasting glucose (0.023) levels from baseline. Our study indicates that short antibiotic cycles can induce acute harmful effects and warrants for further research examining the chronic and accumulated risk of antibiotic exposures. Furthermore, this study highlights the need for research on methods to prevent acute antibiotic-induced glucose control disruption. |
