Chronic curcumin supplementation: Effects on endothelial function following exercise-induced muscle damage

Sanders, Elizabeth

Item

Chronic curcumin supplementation: Effects on endothelial function following exercise-induced muscle damage

Sanders, Elizabeth

Date

2015-11-03

Abstract

Chronic inflammation is linked to endothelial dysfunction. Supplementation with curcumin, an anti-inflammatory, has been proved to improve endothelial function in individuals with chronic inflammation. Exercise-induced muscle damage induces acute inflammation, and can lead to a decrease in endothelial function. Purpose: The purpose of this study was to examine the effects of curcumin on endothelial function after exercise-induced muscle damage in moderately trained individuals. Methods: Seventy-five moderately trained men (n=31) and women (n=32) volunteered for the study. Subjects were randomized into one of three groups for supplementation. The low dosage group received 250mg/day of curcumin (C250), the high dosage group received1000mg/day (C1000), and the placebo (P) group received a similar quantity of powder containing no curcumin. Each subject supplemented for two months. Anaerobic capacity, endothelial function, and baseline anthropometric testing were performed prior to 8 weeks of supplementation. Post supplementation subjects reported to the lab five consecutive days. The same baseline tests were retested followed by a 45 min downhill run at 65% VO2max to induce muscle damage. Endothelial function and blood markers were measured post muscle damage. Results: There was no significant difference between groups for FMD, AUC, and IAUC. There was significant increase in creatine kinase post down hill run in all groups. Conclusion: Curcumin supplementation did not improve endothelial function following exercise induced muscle damage.