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dc.creatorJäger, Ralf
dc.creatorPurpura, Martin
dc.creatorStone, Jason D.
dc.creatorTurner, Stephanie M
dc.creatorAnzalone, Anthony J.
dc.creatorEimerbrink, Micah J.
dc.creatorPane, Marco
dc.creatorAmoruso, Angela
dc.creatorRowlands, David S.
dc.creatorOliver, Jonathan M.
dc.date.accessioned2017-06-29T16:32:07Z
dc.date.available2017-06-29T16:32:07Z
dc.date.issued2016-10-14
dc.identifier.urihttps://doi.org/10.3390/nu8100642
dc.identifier.urihttps://repository.tcu.edu/handle/116099117/19794
dc.identifier.urihttps://www.mdpi.com/2072-6643/8/10/642
dc.description.abstractProbiotics have immunomodulatory effects. However, little is known about the potential benefit of probiotics on the inflammation subsequent to strenuous exercise. In a double-blind, randomized, placebo controlled, crossover design separated by a 21-day washout, 15 healthy resistance-trained men ingested an encapsulated probiotic Streptococcus (S.) thermophilus FP4 and Bifidobacterium (B.) breve BR03 at 5 bn live cells (AFU) concentration each, or a placebo, daily for 3 weeks prior to muscle-damaging exercise (ClinicalTrials.gov NCT02520583). Isometric strength, muscle soreness, range of motion and girth, and blood interleukin-6 (IL-6) and creatine kinase (CK) concentrations were measured from pre- to 72 h post-exercise. Statistical analysis was via mixed models and magnitude-based inference to the standardized difference. Probiotic supplementation resulted in an overall decrease in circulating IL-6, which was sustained to 48 h post-exercise. In addition, probiotic supplementation likely enhanced isometric average peak torque production at 24 to 72 h into the recovery period following exercise (probiotic-placebo point effect ± 90% CI: 24 h, 11% ± 7%; 48 h, 12% ± 18%; 72 h, 8% ± 8%). Probiotics also likely moderately increased resting arm angle at 24 h (2.4% ± 2.0%) and 48 h (1.9% ± 1.9%) following exercise, but effects on soreness and flexed arm angle and CK were unclear. These data suggest that dietary supplementation with probiotic strains S. thermophilus FP4 and B. breve BR03 attenuates performance decrements and muscle tension in the days following muscle-damaging exercise.en_US
dc.language.isoenen_US
dc.publisherMultidisciplinary Digital Publishing Institute
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/
dc.sourceNutrients
dc.subjectisokineticen_US
dc.subjecteccentric exerciseen_US
dc.subjectinflammationen_US
dc.subjectcytokinesen_US
dc.titleProbiotic Streptococcus thermophilus FP4 and Bifidobacterium breve BR03 Supplementation Attenuates Performance and Range-of-Motion Decrements Following Muscle Damaging Exercise
dc.typeArticleen_US
dc.rights.holderJager et al.
dc.rights.licenseCC BY 4.0
local.collegeHarris College of Nursing and Health Sciences
local.departmentKinesiology
local.personsStone, Turner, Anzalone, Eimerbrink, Oliver (KINE)


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