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dc.creatorRequena, Sebastian
dc.creatorPonomarchuk, Olga
dc.creatorCastillo, Marlius K.
dc.creatorRebik, Jonathan
dc.creatorBrochiero, Emmanuelle
dc.creatorBorejdo, Julian
dc.creatorGryczynski, Ignacy
dc.creatorDzyuba, Sergei V.
dc.creatorGryczynski, Zygmunt
dc.creatorGrygorczyk, Ryszard
dc.creatorFudala, Rafal
dc.date.accessioned2019-07-11T15:17:10Z
dc.date.available2019-07-11T15:17:10Z
dc.date.issued2017-12-01
dc.identifier.urihttps://doi.org/10.1038/s41598-017-17037-2
dc.identifier.urihttps://repository.tcu.edu/handle/116099117/26385
dc.identifier.urihttps://www.nature.com/articles/s41598-017-17037-2
dc.description.abstractAbnormalities of mucus viscosity play a critical role in the pathogenesis of several respiratory diseases, including cystic fibrosis. Currently, there are no approaches to assess the rheological properties of mucin granule matrices in live cells. This is the first example of the use of a molecular rotor, a BODIPY dye, to quantitatively visualize the viscosity of intragranular mucin matrices in a large population of individual granules in differentiated primary bronchial epithelial cells using fluorescence lifetime imaging microscopy.
dc.language.isoenen_US
dc.publisherNature Publishing Group
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/
dc.sourceScientific Reports
dc.subjectBiophysics
dc.subjectChemical tools
dc.titleImaging viscosity of intragranular mucin matrix in cystic fibrosis cells
dc.typeArticle
dc.rights.holderRequena et al.
dc.rights.licenseCC BY 4.0
local.collegeCollege of Science and Engineering
local.departmentChemistry and Biochemistry
local.departmentPhysics and Astronomy
local.personsCastillo, Rebik, Dzyuba (CHEM); Gryczynski (PHYS)


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