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dc.creatorGonzález-Parra, Gilberto
dc.creatorDe Ridder, Filip
dc.creatorHuntjens, Dymphy
dc.creatorRoymans, Dirk
dc.creatorIspas, Gabriela
dc.creatorDobrovolny, Hana M.
dc.description.abstractInfluenza and respiratory syncytial virus (RSV) cause acute infections of the respiratory tract. Since the viruses both cause illnesses with similar symptoms, researchers often try to apply knowledge gleaned from study of one virus to the other virus. This can be an effective and efficient strategy for understanding viral dynamics or developing treatment strategies, but only if we have a full understanding of the similarities and differences between the two viruses. This study used mathematical modeling to quantitatively compare the viral kinetics of in vitro RSV and influenza virus infections. Specifically, we determined the viral kinetics parameters for RSV A2 and three strains of influenza virus, A/WSN/33 (H1N1), A/Puerto Rico/8/1934 (H1N1), and pandemic H1N1 influenza virus. We found that RSV viral titer increases at a slower rate and reaches its peak value later than influenza virus. Our analysis indicated that the slower increase of RSV viral titer is caused by slower spreading of the virus from one cell to another. These results provide estimates of dynamical differences between influenza virus and RSV and help provide insight into the virus-host interactions that cause observed differences in the time courses of the two illnesses in patients.en_US
dc.publisherPublic Library of Science
dc.sourcePLOS ONE
dc.subjectInfluenza virusesen_US
dc.subjectImmune responseen_US
dc.subjectRespiratory infectionsen_US
dc.subjectMass diffusivityen_US
dc.subjectRespiratory syncytial virus infectionen_US
dc.titleA comparison of RSV and influenza in vitro kinetic parameters reveals differences in infecting timeen_US
dc.rights.holderGonzalez-Parra et al
dc.rights.licenseCC BY 4.0
local.collegeCollege of Science and Engineering
local.departmentPhysics & Astronomy
local.personsGonzalez-Parra, Dobrovolny (PHYS)

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