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dc.creatorJeffrey Gassen
dc.creatorProkosch, Marjorie L.
dc.creatorMakhanova, Anastasia
dc.creatorEimerbrink, Micah J.
dc.creatorWhite, Jordon D.
dc.creatorProffitt Leyva, Randi P.
dc.creatorPeterman, Julia L.
dc.creatorNicolas, Sylis C.
dc.creatorReynolds, Tania A.
dc.creatorManer, Jon K.
dc.creatorMcNulty, James K.
dc.creatorEckel, Lisa A.
dc.creatorNikonova, Larissa
dc.creatorBrinkworth, Jessica F.
dc.creatorPhillips, Melody D.
dc.creatorMitchell, Joel B.
dc.creatorBoehm, Gary W.
dc.creatorHill, Sarah E.
dc.description.abstractHere, we present a mechanistically grounded theory detailing a novel function of the behavioral immune system (BIS), the psychological system that prompts pathogen avoidance behaviors. We propose that BIS activity allows the body to downregulate basal inflammation, preventing resultant oxidative damage to DNA and promoting longevity. Study 1 investigated the relationship between a trait measure of pathogen avoidance motivation and in vitro and in vivo proinflammatory cytokine production. Study 2 examined the relationship between this same predictor and DNA damage often associated with prolonged inflammation. Results revealed that greater trait pathogen avoidance motivation predicts a) lower levels of spontaneous (but not stimulated) proinflammatory cytokine release by peripheral blood mononuclear cells (PBMCs), b) lower plasma levels of the proinflammatory cytokine interleukin-6 (IL-6), and c) lower levels of oxidative DNA damage. Thus, the BIS may promote health by protecting the body from the deleterious effects of inflammation and oxidative stress.en_US
dc.publisherPublic Library of Science
dc.sourcePLOS ONE
dc.subjectOxidative stressen_US
dc.subjectInflammatory diseasesen_US
dc.subjectDNA damageen_US
dc.subjectImmune systemen_US
dc.titleBehavioral immune system activity predicts downregulation of chronic basal inflammationen_US
dc.rights.holderJeffrey Gassen et al.
dc.rights.licenseCC BY 4.0
local.collegeCollege of Science and Engineering
local.collegeHarris College of Nursing and Health Sciences
local.personsGassen, Eimerbrink, White, Proffitt Layva, Peterman, Nicolas, Phillips, Boehm, Hill (PSYC); Mitchell (KINE)

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