Effects of HCV Protein NS5A on Antiviral Gene Expression

dc.contributor.advisor	Akkaraju, Giridhar
dc.contributor.author	Taetz, Sarah
dc.date	5/19/2019
dc.date.accessioned	2019-09-25T20:41:26Z
dc.date.available	2019-09-25T20:41:26Z
dc.date.issued	2019
dc.identifier.uri	https://repository.tcu.edu/handle/116099117/27010
dc.description.abstract	Hepatitis C virus (HCV) currently infects about 170 million people worldwide. HCV protein NS5A is a known inhibitor of the host innate immune response, specifically, the IFN-b production pathway. However, little is known about the overall structure of the NS5A protein and where NS5A interacts with this pathway. The goal of our study was to determine the effects of two different NS5A mutants, K2040 (10A) and L2198S (H27), on IFN-b promoter activity, as well as to determine which NS5A domain is particularly involved in blocking the IFN-b production pathway.
dc.title	Effects of HCV Protein NS5A on Antiviral Gene Expression
etd.degree.department	Biology
local.college	College of Science and Engineering
local.college	John V. Roach Honors College
local.department	Biology

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