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dc.contributor.advisorMueller, Kathyrne J.
dc.contributor.authorWhiteside, David A.en_US
dc.date.accessioned2019-10-11T15:11:31Z
dc.date.available2019-10-11T15:11:31Z
dc.date.created1989en_US
dc.date.issued1989en_US
dc.identifieraleph-441440en_US
dc.identifier.urihttps://repository.tcu.edu/handle/116099117/34784
dc.description.abstractRats receiving intra-accumbal infusions of 10 ng cholecystokinin (CCK) and/or 1 ng met-enkephalin (ENK) were subsequently injected with d-amphetamine (AMPH) and observed for 100 min in an open field. Rears, numbers of lines crossed, and locomotor stereotypy (using the new gamma statistic) were measured. In the absence of AMPH, rats infused with CCK and/or ENK did not differ from AMPH controls on any behavioral measures. AMPH increased the numbers of rears and lines crossed, and also induced stereotypic patterns of locomotions. In AMPH treated rats however, CCK reduced the number of lines crossed and potentiated locomotor stereotypy. ENK had no effect when given with AMPH, but when administered with both CCK and AMPH, ENK blocked the potentiating effect of CCK on AMPH-induced locomotor stereotypy. These results indicate that ENK interacts with CCK in nucleus accumbens to modulate amphetamine-induced locomotor stereotypy. Moreover, the behavioral effects of ENK in nucleus accumbens are limited to specific aspects of locomotor behavior since it produced no changes in lines crossed. The results of this study contribute to an ongoing investigation into locomotor stereotypy and into the behavioral effects of peptide-transmitter interactions in brain.
dc.format.extentix, 82 leaves, bounden_US
dc.format.mediumFormat: Printen_US
dc.language.isoengen_US
dc.relation.ispartofTexas Christian University dissertationen_US
dc.relation.ispartofAS38.W495en_US
dc.subject.lcshAmphetaminesen_US
dc.subject.lcshCholecystokininen_US
dc.subject.lcshLocomotion--Physiologyen_US
dc.titleIntra-accumbal infusions of cholecystokinin and enkephalin modulate amphetamine-induced locomotor behavioren_US
dc.typeTexten_US
etd.degree.departmentDepartment of Psychology
etd.degree.levelDoctoral
local.collegeCollege of Science and Engineering
local.departmentPsychology
local.academicunitDepartment of Psychology
dc.type.genreDissertation
local.subjectareaPsychology
dc.identifier.callnumberMain Stacks: AS38 .W495 (Regular Loan)
dc.identifier.callnumberSpecial Collections: AS38 .W495 (Non-Circulating)
etd.degree.nameDoctor of Philosophy
etd.degree.grantorTexas Christian University


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