dc.contributor.advisor | Boehm, Gary W. | |
dc.contributor.author | Sparkman, Nathan L. | en_US |
dc.date.accessioned | 2019-10-11T15:11:34Z | |
dc.date.available | 2019-10-11T15:11:34Z | |
dc.date.created | 2004 | en_US |
dc.date.issued | 2004 | en_US |
dc.identifier | aleph-1060464 | en_US |
dc.identifier | Microfilm Diss. 849. | en_US |
dc.identifier.uri | https://repository.tcu.edu/handle/116099117/34877 | |
dc.description.abstract | Peripheral administration of lipopolysaccharide (LPS) or interleukin-1 (IL-1) may lead to alterations of CNS function and behavioral changes designated ¿sickness behavior.¿ Further, some experiments show evidence of LPS- and cytokine-mediated alterations in learning and memory. The current study examined the effects of intraperitoneal LPS injections on behavior in a two-way active avoidance conditioning paradigm. Subjects were able to avoid the mild shock stimulus, escape it, or simply endure it. In a series of experiments, subjects treated with LPS 4 hrs prior to testing on day 1, day 2 or every day showed impaired learning by exhibiting fewer avoidance responses than controls. Furthermore, an LPS-induced increase in non-cued inter-trial interval (ITI) crossings was observed during the last portion of testing, suggesting that a significant percentage of their avoidance responses were not conditioned. LPS injections administered immediately after testing on day 1 or 4 hrs prior to testing on day 4 did not produce decrements in the number of avoidance responses. The results suggest that, when administered at specific time points, LPS is capable of altering two-way active avoidance conditioning. Furthermore, LPS-treated animals' behavior suggests that they failed to form a strong association between conditioned stimulus (CS) and unconditioned stimulus (US). These results support the theory that peripheral immune stimuli may induce deleterious effects on learning, and extend the work to a negatively reinforced operant procedure. | |
dc.format.extent | vi, 59 leaves : illustrations | en_US |
dc.format.medium | Format: Print | en_US |
dc.language.iso | eng | en_US |
dc.relation.ispartof | Texas Christian University dissertation | en_US |
dc.relation.ispartof | AS38.S6596 | en_US |
dc.subject.lcsh | Sick--Psychology | en_US |
dc.subject.lcsh | Immune system | en_US |
dc.subject.lcsh | Cytokines | en_US |
dc.subject.lcsh | Endotoxins | en_US |
dc.title | Peripheral immune activation, cytokines, and behavior: effects of endotoxin exposure on two-way active avoidance conditioning | en_US |
dc.type | Text | en_US |
etd.degree.department | Department of Psychology | |
etd.degree.level | Doctoral | |
local.college | College of Science and Engineering | |
local.department | Psychology | |
local.academicunit | Department of Psychology | |
dc.type.genre | Dissertation | |
local.subjectarea | Psychology | |
dc.identifier.callnumber | Main Stacks: AS38 .S6596 (Regular Loan) | |
dc.identifier.callnumber | Special Collections: AS38 .S6596 (Non-Circulating) | |
etd.degree.name | Doctor of Philosophy | |
etd.degree.grantor | Texas Christian University | |