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dc.creatorSinghania, Girish
dc.creatorEjaz, Abutaleb A.
dc.creatorMcCullough, Peter A.
dc.creatorKluger, Aaron Y.
dc.creatorBalamuthusamy, Saravanan
dc.creatorDass, Bhagwan
dc.creatorSinghania, Namrata
dc.creatorAgarwal, Adhish
dc.description.abstractRandomized controlled trials have demonstrated the benefits of guideline-directed medical therapy in the outpatient setting for treatment of chronic heart failure. However, the benefits of continuation (or discontinuation) of major chronic heart failure therapies when treating acute heart failure during hospitalization are less clear. Real and anticipated worsening renal function, hyperkalemia and hypotension are the three major reasons for discontinuation of renin-angiotensin-aldosterone system inhibitors during hospitalization, and a failure to resume renin-angiotensin-aldosterone system inhibitors before discharge could worsen cardiovascular outcomes. Available data, mostly observational, shows that continuation or initiation of renin-angiotensin-aldosterone system inhibitors appears efficacious, safe, and well tolerated in majority of acute heart failure patients during hospitalization. Worsening renal function portends poor prognosis only if associated with congestion in acute heart failure, and clinicians should not de-escalate diuretic therapy routinely for worsening renal function.
dc.publisherIMR Press
dc.sourceReviews in Cardiovascular Medicine
dc.subjectAcute heart failure
dc.subjectcardiorenal syndrome
dc.subjectcardiovascular outcomes
dc.subjectmedication continuation
dc.subjectmedication discontinuation
dc.titleContinuation of Chronic Heart Failure Therapies During Heart Failure Hospitalization - a Review
dc.rights.holder2019 Singhania et al
dc.rights.licenseCC BY 4.0
local.collegeBurnett School of Medicine
local.departmentBurnett School of Medicine
local.personsBalamuthusamy (SOM)

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