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dc.contributor.authorFranks, Sarah Elizabethen_US
dc.date.accessioned2014-07-22T18:48:54Z
dc.date.available2014-07-22T18:48:54Z
dc.date.created2013en_US
dc.date.issued2013en_US
dc.identifierTCU Master Thesisen_US
dc.identifieretd-05232013-111215en_US
dc.identifierumi-10402en_US
dc.identifiercat-001999992en_US
dc.identifier.urihttps://repository.tcu.edu:443/handle/116099117/4467
dc.descriptionTitle from thesis title page (viewed Jul. 25, 2013).en_US
dc.descriptionIncludes abstract.en_US
dc.descriptionThesis--Texas Christian University, 2013.en_US
dc.descriptionDepartment of Biology; advisor, Shauna M. McGillivray.en_US
dc.descriptionIncludes bibliographical references.en_US
dc.descriptionText (electronic thesis) in PDF.en_US
dc.description.abstractBacillus anthracis must avoid an array of antibacterial defenses by the host during infection. Although anthrax toxin and capsule, located on extra-chromosomal plasmids, play important roles in the pathogenesis of this disease, evidence indicates chromosomal genes also contribute. A random chromosomal mutant library of B. anthracis Sterne was employed to identify novel chromosomal virulence factors. Mutants were screened for loss of virulence in Caenorhabditis elegans. Those unable to infect C. elegans were selected for and the site of transposon insertion was identified. The most highly attenuated mutant had a disruption in an operon containing multiple tellurium resistance genes, leading to an increased susceptibility to potassium tellurite as well as host defenses (ROS and AMPs). In addition, the mutant displays attenuated virulence in whole blood and macrophage survival in comparison to WT. We conclude the tellurium resistance operon of B. anthracis has a novel role in resistance to critical host defenses.en_US
dc.format.mediumFormat: Onlineen_US
dc.publisher[Fort Worth, Tex.] : Texas Christian University,en_US
dc.relation.ispartofUMI thesis.en_US
dc.relation.requiresMode of access: World Wide Web.en_US
dc.relation.requiresSystem requirements: Adobe Acrobat reader.en_US
dc.titleA novel role for tellurium resistance genes in the pathogenesis of Bacillus anthracis [electronic resource] /en_US
dc.typeTexten_US
etd.degree.departmentDepartment of Biology
etd.degree.levelMaster
local.academicunitDepartment of Biology
local.subjectareaBiology


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